Neither the Dragons or Warriors can make the grand final after consecutive defeats, but they'll both be desperate to finish their campaigns with a victory.
St George Illawarra provided glimpses of their class as they threatened a comeback against the champion Broncos last Saturday but ultimately went down 18-4 and copped injuries in the process.
The Warriors showed promise in round one but regressed slightly in a 22-12 defeat to the Roosters after which coach Brad Donald admitted it's been challenging to get the new-look team to click.
Dragons: St George Illawarra will have one less player on the bench after Maddie Studdon (ankle), Tiana Penitani (knee) and Shakiah Tungai (shoulder) were all ruled out on game day.
The Dragons had only named a 19-woman squad on Tuesday after injuries to Kezie Apps (knee) and Isabelle Kelly (ankle) and Shaylee Bent's suspension.
Bench duo Georgia Page and Talei Holmes are promoted to start.Tiana Penitani moves to the centres and winger Rikeya Horne included for her first game of the campaign.
Keeley Davis has officially swapped from hooker to five-eighth with Aaliyah Fasavalu-Fa'amausili doing the reverse. Jade Etherden and Teagan Berry are the new faces on the pine. The Dragons have won two from two against the Warriors.
Warriors: Teaghan Hartigan starts in the second row with Shaniah Power to come off the bench, while Laken Paitai replaces 16 on the interchange. Stephanie Ball was the other player to drop out of the extended squad on game day after Kanyon Paul and Brianna Clark were omitted 24 hours before kick-off.
Simone Smith has been benched with Naomi Kara in at halfback. Samantha Economos is set to start at prop, Hilda Peters at hooker and Shaniah Power in the second row with Kayla Sauvao and Kanyon Paul dropping out. Teaghan Hartigan and Taimane Levu are the new names on the bench.
Centre Evania Pelite has scored in back-to-back games in 2020.
The Dragons must be alert in defence because the Warriors have thrown more offloads (19) than anyone else so far this year. The Broncos have produced 18 while St George Illawarra have managed 15.