The Saturday night fixture will kick off at 7.30pm.
Since the joint-venture, the Dragons have enjoyed a strong record over Souths.
In 2007, Souths defeated the Dragons at Wollongong 24-14 late in the season.
A returned serve, in 2010 saw the Dragons end Souths' finals hopes, defeating them 40-24 at WIN Jubilee Oval in Round 26.
In the 2013 campaign, the Dragons faced Souths in Round 19, defeating them 22-18 at ANZ Stadium in a nail-biting golden point thriller.
The full NRL Draw is set to be released Wednesday December, 4