This is more than just a rematch of the 2019 grand final, the Dragons are effectively playing for their season in Saturday's match at Bankwest Stadium.
After suffering a 18-4 loss to the Roosters in their opening-round fixture St George Illawarra need a win to keep their chances alive.
Brisbane, on the other hand, look the goods once again. After a slowish start they took care of business against the Warriors to show they remain the team to beat.
The battle between rival No.7s Maddie Studdon and Ali Brigginshaw is one worth watching.
Dragons: Shakiah Tungai (shoulder) is out, with Aaliyah Fasavalu-Fa'amausili named at five-eighth and Georgia Page joining the bench. Rikeya Horne also dropped out of the squad an hour before kick-off.
Maddison Weatherall and Jade Etherden were omitted 24 hours before kick-off.
Broncos: Lock Tarryn Aiken switches roles with star halfback Ali Brigginshaw, and Tallisha Harden starts in the second row with Jesski Elliston to come off the bench. Romy Teitzel and Tyler Birch were omitted from the squad on game day.
Five-eighth Raecene McGregor was stretchered off with a neck issue against the Warriors but thankfully is OK. Chante Temara and Zara Canfield were left out the day before the match.
Steph Hancock v Millie Boyle: The former teammates will go head-to-head. Hancock made 29 tackles and ran for 73 metres in round one while Boyle ran for 89 metres and made 21 tackles. Both sets of backs will be hoping their front-rowers can set them up to turn field position into points.
Tamika Upton's hat-trick against the Warriors was the just the second in the history of the competition. The first woman to achieve that feat was Kimiroa Nati in the 2018 grand final.